Nov 23, 2024  
2024-2025 Undergraduate Catalog 
    
2024-2025 Undergraduate Catalog
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CH 231 - Organic Chemistry II (CBL-R)


Credits: 4

This course is the second half of a two-semester survey of organic chemistry, with a focus on reaction mechanisms and organic synthesis. Students will use foundational knowledge of molecular structure and reactivity gained in Chemistry 230 to build problem-solving skills in organic reaction mechanism and synthesis. Practical applications in multi-step synthesis, isolation, purification, and structural elucidation of organic compounds will be gained in the laboratory. Chemistry of biologically significant small molecules, including natural products and active pharmaceutical ingredients (APIs) will also be explored.

This is a Community-Based Learning - Required (CBL-R)  course.

Prerequisite/Corequisite
Prerequisite: CH 230 or permission of instructor.

Learning Outcomes
Upon completion of this course, students will be able to:

  • Describe and investigate properties of new functional groups and molecular structures using fundamental principles of bonding, stereochemistry, and conformational analysis.
  • Examine, predict, and explain reactivity patterns of organic functional groups by employing (1) electron flow arrow-pushing mechanisms, (2) molecular orbital interactions, and (3) principles of chemical thermodynamics and kinetics. Students will do this in the context of the following reaction types: electrophilic additions to C-C -bonds, nucleophilic additions to C-O - bonds, chemistry at the alpha position, and conjugate addition.
  • Propose multi-step syntheses of simple small organic molecules using functional group manipulations and retrosynthetic analysis.
  • Plan and execute multi-step organic synthesis of small molecules by employing basic organic laboratory techniques including reaction set-up, and the isolation, purification, and spectroscopic characterization of compounds.
Notes
Laboratory, done on a micro-scale basis, emphasizes techniques, characterization and synthesis of representative compounds: 3 hours per week.



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