Feb 09, 2023
CH 335 - Medicinal Chemistry
Credits: 4 credits
An overview of medicinal chemistry with a focus on the intersection of synthetic organic chemistry, biochemistry, and pharmaceutical chemistry. Students investigate the organic chemistry of drug design and the synthesis of small molecule therapeutics. Students use the primary literature, case studies, along with other supplementary readings to navigate these topics. The laboratory component allows students to explore questions related to drug discoverry and cultivate fundamental skills necessary to design, synthesize and analyze potential APIs (active pharmaceutical ingredients).
Prerequisites: Completion of CH230 and CH231 (C- or betterr in both courses); concurrent enrollment in CH231 with B- or better in CH230.
Expected Learning Outcomes:
Upon completion of this course, the student will be able to do the following:
- Critically analyze the primary scientific literature.
- Interpret SAR (structure-activity-relationship) data and prepare chemical modifications to address improvements in biological activity or pharmacokinetic properties.
- Examine drug-receptor interactions and enzyme inhibition / inactivation at the molecular level by applying 3-dimensional molecular analysis and fundamentals of chemical bonding and reactivity.
- Synthesize, isolate, purify, and characterize small molecules in the laboratory using modern organic synthesis techniques.
- Clearly articulate scientific background, results, data analysis, and conclusions by completing “peer reviewed” scientific writing assignments.
- Effectively communicate scientific data with peers and faculty, and demonstrate this by presenting a scientific talk or poster.
Frequency of Offering:
At a minimum, alternate years, or based on demand.
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